The bare essentials: Functional symptoms in neurology.

The bare essentials: coma.

The bare essentials: hyperkinetic movement disorders: shakes, jumps and jolts.

2010;10:114–123. doi:10.1136/ jnnp.2010.206078 114 INTRODUCTION Movement disorders involve either too much or too little movement. One of the most common and important is Parkinson’s disease where there is a mixture of too little (bradykinesia) and too much movement (tremor and drug induced dyskinesia); this is the subject for a future Bare Essentials article and will not be considered here. Hy...

The bare essentials: muscle disease.

Correspondence to: Professor M G Hanna, MRC Centre for Neuromuscular Diseases, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; [email protected] Muscle diseases impair mobility and frequently have cardiorespiratory complications. Their age of onset is extremely wide; patients may die young, or there may be lifelong motor disabil...

THE BARE ESSENTIALS Peripheral nerve diseases

Correspondence to: Professor R Hughes, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; richard. [email protected] EPIDEMIOLOGY Peripheral nerve diseases are surprisingly common. Population-based studies indicate a prevalence of symmetrical polyneuropathy of about 2.4%, more in the elderly. Carpal tunnel synd...

O 24: Functional Role of The K2p Potassium Channel Task-3 in A Syngeneic Murine Glioma Model

To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...